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About CML
What is CML?
CML stands for chronic myeloid leukemia
CML is a type of cancer that affects the blood-forming cells in the bone marrow. In CML, these blood-forming cells make too many white blood cells, called granulocytes.
These immature white blood cells (sometimes called blast cells or leukemic blasts) crowd out other types of healthy blood cells. This is a problem because it can lead to your body not having enough of the healthy blood cells that perform important functions in the body.

Here’s what happens to normal blood cells in people with CML.
Over time, excess leukemic cells crowd out healthy white blood cells, red blood cells, and platelets. This can cause problems with your health, such as anemia which is when the body does not have enough healthy red blood cells. This can also cause bruising easily, bleeding that takes longer to stop, and a higher chance of infections.
One of the ways to know how many leukemic cells are in the body is through a special test called a standardized polymerase chain reaction test, also known as a PCR test.

There are many ways to connect with other CML voices
There are social communities you can join to hear from others living with CML to learn more about their experiences.
What are common CML symptoms?
Everyone’s experience with CML is different, but there are symptoms that many people share. Common symptoms of CML include, but are not limited to:

Weakness

Fatigue (extreme tiredness)

Night sweats

Weight loss

Fever

Bone pain

An enlarged spleen (felt as a mass under the left side of the ribcage)

Pain or a sense of "fullness" in the belly

Feeling full after eating even a small amount of food
One or more of these symptoms can have a big impact on your day-to-day life.
For more information about CML, visit these websites
No matter how CML affects your body, it is a good idea to keep track of the symptoms and side effects you are having
Tracking your symptoms has many benefits. It can help you:

See changes over time

Talk with your doctor about your experience

Better understand your physical health
Even minor CML symptoms and side effects can get in the way of living everyday life. Be sure to track any symptoms you have, so you can discuss them with your doctor at your next visit. Tracking symptoms and side effects, is a good way to better understand your physical health.

All cancers come with struggles and hardships. It’s important that you always feel comfortable talking about any difficulties.
Your experience matters. It’s important to talk with your doctor about CML and your experience with CML.
References:
- [NCI2024-CML] National Cancer Institute (NCI). Chronic myeloid leukemia. NCI Dictionary of Cancer Terms.
- https://www.cancer.gov/publications/dictionaries/cancer-terms/def/chronic-myeloid-leukemia. Accessed May 29, 2024.
[MayClinic2024-CML] Mayo Clinic. Chronic myelogenous leukemia. https://www.mayoclinic.org/diseases-conditions/chronic-myelogenous-leukemia/symptomscauses/syc-20352417. Accessed May 29, 2024. - [ACS2024-CML] American Cancer Society (ACS). What Is Chronic Myeloid Leukemia? https://www.cancer.org/cancer/types/chronic-myeloid-leukemia/about/what-is-cml.html. Accessed June 25, 2024.
- [NCI2024-RBC] National Cancer Institute. Red blood cell. NCI Dictionary of Cancer Terms. https://www.cancer.gov/publications/dictionaries/cancerterms/search/red%20blood%20cell/?searchMode=Begins. Accessed May 29, 2024
- [NCI2024-WBC] National Cancer Institute. White blood cell. NCI Dictionary of Cancer Terms. https://www.cancer.gov/publications/dictionaries/cancer-terms/def/white-blood-cell. Accessed June 25, 2024
- [NCI2024-Platelet] National Cancer Institute. Platelet. NCI Dictionary of Cancer Terms. https://www.cancer.gov/publications/dictionaries/cancer-terms/def/platelet. Accessed June 25, 2024
- [ACS2024-CMLtests] American Cancer Society (ACS). Tests for Chronic Myeloid Leukemia. https://www.cancer.org/cancer/types/chronic-myeloid-leukemia/detection-diagnosis-staging/howdiagnosed.html. Accessed June 25, 2024.
- [NCI2024-CMLstats] NIH National Cancer Institute. Cancer Stat Facts: Leukemia - CML. https://seer.cancer.gov/statfacts/html/cmyl.html Accessed May 29, 2024.
- [LLS2023-CML] Leukemia & Lymphoma Society. Chronic Myeloid Leukemia PDF. Revised 2023. Page 10. https://www.lls.org/sites/default/files/2023-06/PS31_CML_2023.pdf. Accessed May 29, 2024.
- [Lizan2021] Lizán L, et al. Additional Value of Patient-Reported Symptom Monitoring in Cancer Care: A Systematic Review of the Literature. Cancers (Basel). 2021;13(18):4615.
Remember — your voice matters! Learn more about how to share your experience with your doctor. Contact your doctor right away about any side effects and to discuss your experiences.
References:
- [LLS2023-CML] Leukemia & Lymphoma Society. Chronic Myeloid Leukemia PDF. Revised 2023. Page 10. https://www.lls.org/sites/default/files/2023-06/PS31_CML_2023.pdf. Accessed May 29, 2024.
- [ACS2024-CMLtests] American Cancer Society. Tests for Chronic Myeloid Leukemia. https://www.cancer.org/cancer/chronic-myeloid-leukemia/detection-diagnosis-staging/howdiagnosed.html. Accessed May 30, 2024.